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EEG

Characteristic EEG changes in sporadic CJD are periodic bi- and triphasic waves (periodic sharp wave complexes, PSWCs).

(Figures EEG1, EEG2)

 

EEG criteria used in the diagnosis of CJD

- Periodc "sharp-wave" complexes (PSWCs)

- Periodicity (most important criterion)

- Frequency 0.5-2/sec

- Duration between 100 und 600 msec

- Amplitude higher than 150 μV-300 μV

- Generalized activity, with a maximum over the frontal region, partly also lateralized

- Sometimes followed by burst suppression"